Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

Kathleen M. Mulder; Alan E. Levine; Xochil Hernandez; Mary K. McKnight; Diane E. Brattain; Michael G. Brattain

doi:10.1016/0006-291X(88)90449-4

Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

Kathleen M. Mulder, Alan E. Levine, Xochil Hernandez, Mary K. McKnight, Diane E. Brattain, Michael G. Brattain

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Abstract

Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.

Original language	English (US)
Pages (from-to)	711-716
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(88)90449-4
State	Published - Jan 29 1988

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells",

abstract = "Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.",

author = "Mulder, {Kathleen M.} and Levine, {Alan E.} and Xochil Hernandez and McKnight, {Mary K.} and Brattain, {Diane E.} and Brattain, {Michael G.}",

note = "Funding Information: This work was supported by the National Cancer Institute. Abbreviations Used: TGF-0, EGF, epidermal growth factor; 4-(2-hydroxyethyl)-1-pdperazineethanesulfonic sodium dodecyl sulfate; SSC,",

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T1 - Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

AU - Mulder, Kathleen M.

AU - Levine, Alan E.

AU - Hernandez, Xochil

AU - McKnight, Mary K.

AU - Brattain, Diane E.

AU - Brattain, Michael G.

N1 - Funding Information: This work was supported by the National Cancer Institute. Abbreviations Used: TGF-0, EGF, epidermal growth factor; 4-(2-hydroxyethyl)-1-pdperazineethanesulfonic sodium dodecyl sulfate; SSC,

PY - 1988/1/29

Y1 - 1988/1/29

N2 - Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.

AB - Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.

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Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

Abstract

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