Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

Kathleen M. Mulder, Alan E. Levine, Xochil Hernandez, Mary K. McKnight, Diane E. Brattain, Michael G. Brattain

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Previous work indicated that transforming growth factor-β elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-β in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-β-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-β. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-β.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jan 29 1988

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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