Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Jeffrey M. Peters; Jose L. Morales; Frank J. Gonzalez

doi:10.1016/j.ddmec.2011.11.002

Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Jeffrey M. Peters, Jose L. Morales, Frank J. Gonzalez

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Critical physiological roles of peroxisome proliferatoractivated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.

Original language	English (US)
Pages (from-to)	e85-e93
Journal	Drug Discovery Today: Disease Mechanisms
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ddmec.2011.11.002
State	Published - 2011

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ddmec.2011.11.002

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@article{30b69fe3739c45b88c16f7a2f80883dc,

title = "Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)",

abstract = "Critical physiological roles of peroxisome proliferatoractivated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.",

author = "Peters, \{Jeffrey M.\} and Morales, \{Jose L.\} and Gonzalez, \{Frank J.\}",

note = "Funding Information: Our research is supported by the National Institutes of Health ( CA124533 , CA126826 , CA141029 , CA140369 , AA018863 ) J.M.P. and the National Cancer Institute Intramural Research Program ( ZIABC005561 , ZIABC005562 , ZIABC005708 ) F.J.G.",

year = "2011",

doi = "10.1016/j.ddmec.2011.11.002",

language = "English (US)",

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pages = "e85--e93",

journal = "Drug Discovery Today: Disease Mechanisms",

issn = "1740-6765",

publisher = "Elsevier Ltd",

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T1 - Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

AU - Peters, Jeffrey M.

AU - Morales, Jose L.

AU - Gonzalez, Frank J.

N1 - Funding Information: Our research is supported by the National Institutes of Health ( CA124533 , CA126826 , CA141029 , CA140369 , AA018863 ) J.M.P. and the National Cancer Institute Intramural Research Program ( ZIABC005561 , ZIABC005562 , ZIABC005708 ) F.J.G.

PY - 2011

Y1 - 2011

N2 - Critical physiological roles of peroxisome proliferatoractivated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.

AB - Critical physiological roles of peroxisome proliferatoractivated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of metabolic diseases or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of colon cancer.

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U2 - 10.1016/j.ddmec.2011.11.002

DO - 10.1016/j.ddmec.2011.11.002

M3 - Review article

AN - SCOPUS:84857643155

SN - 1740-6765

VL - 8

SP - e85-e93

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 3-4

ER -

Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Abstract

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