Modulation of the baroreceptor reflex by stimulation of the hypothalamic defense and vigilance areas

Yu Fei Duan; Ray W. Winters; Philip M. Mccabe; Edward J. Green; Ying Huang; Neil Schneiderman

doi:10.1016/0031-9384(95)02145-0

Modulation of the baroreceptor reflex by stimulation of the hypothalamic defense and vigilance areas

Yu Fei Duan, Ray W. Winters, Philip M. Mccabe, Edward J. Green, Ying Huang, Neil Schneiderman

Department of Psychiatry and Behavioral Health

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Electrical stimulation of the hypothalamic defense area (HDA) elicits a pressor/tachycardia response that is believed to prepare an animal for fight or flight. In contrast, electrical stimulation of the hypothalamic vigilance area (HVA) evokes a pressor/bradycardia response that is associated with the inhibition of movement. The differences in the behavioral components of these two affective response patterns suggest differential modulation of the baroreceptor reflex. The present study tested this idea by assessing the effects of electrical stimulation of the HDA and the HVA upon the bradycardia/depressor response elicited by stimulation of the aortic nerve (AN) in rabbits. Concurrent HDA and AN stimulation was observed to attenuate the AN-elicited bradycardia but enhanced the depressor response elicited by AN stimulation. In contrast, concurrent stimulation of the HVA and AN enhanced the bradycardia elicited by AN stimulation but reduced the magnitude of the AN-elicited depressor response. These results provide evidence for differential modulation of the baroreceptor reflex during the defense and vigilance reactions.

Original language	English (US)
Pages (from-to)	1093-1098
Number of pages	6
Journal	Physiology and Behavior
Volume	59
Issue number	6
DOIs	https://doi.org/10.1016/0031-9384(95)02145-0
State	Published - Jun 1996

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(95)02145-0

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@article{74993d9fad3f47be86dba5006528215c,

title = "Modulation of the baroreceptor reflex by stimulation of the hypothalamic defense and vigilance areas",

abstract = "Electrical stimulation of the hypothalamic defense area (HDA) elicits a pressor/tachycardia response that is believed to prepare an animal for fight or flight. In contrast, electrical stimulation of the hypothalamic vigilance area (HVA) evokes a pressor/bradycardia response that is associated with the inhibition of movement. The differences in the behavioral components of these two affective response patterns suggest differential modulation of the baroreceptor reflex. The present study tested this idea by assessing the effects of electrical stimulation of the HDA and the HVA upon the bradycardia/depressor response elicited by stimulation of the aortic nerve (AN) in rabbits. Concurrent HDA and AN stimulation was observed to attenuate the AN-elicited bradycardia but enhanced the depressor response elicited by AN stimulation. In contrast, concurrent stimulation of the HVA and AN enhanced the bradycardia elicited by AN stimulation but reduced the magnitude of the AN-elicited depressor response. These results provide evidence for differential modulation of the baroreceptor reflex during the defense and vigilance reactions.",

author = "Duan, {Yu Fei} and Winters, {Ray W.} and Mccabe, {Philip M.} and Green, {Edward J.} and Ying Huang and Neil Schneiderman",

note = "Funding Information: The present study was supported by NIH grants HL 36588 and HL 07426.",

year = "1996",

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doi = "10.1016/0031-9384(95)02145-0",

language = "English (US)",

volume = "59",

pages = "1093--1098",

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T1 - Modulation of the baroreceptor reflex by stimulation of the hypothalamic defense and vigilance areas

AU - Duan, Yu Fei

AU - Winters, Ray W.

AU - Mccabe, Philip M.

AU - Green, Edward J.

AU - Huang, Ying

AU - Schneiderman, Neil

N1 - Funding Information: The present study was supported by NIH grants HL 36588 and HL 07426.

PY - 1996/6

Y1 - 1996/6

N2 - Electrical stimulation of the hypothalamic defense area (HDA) elicits a pressor/tachycardia response that is believed to prepare an animal for fight or flight. In contrast, electrical stimulation of the hypothalamic vigilance area (HVA) evokes a pressor/bradycardia response that is associated with the inhibition of movement. The differences in the behavioral components of these two affective response patterns suggest differential modulation of the baroreceptor reflex. The present study tested this idea by assessing the effects of electrical stimulation of the HDA and the HVA upon the bradycardia/depressor response elicited by stimulation of the aortic nerve (AN) in rabbits. Concurrent HDA and AN stimulation was observed to attenuate the AN-elicited bradycardia but enhanced the depressor response elicited by AN stimulation. In contrast, concurrent stimulation of the HVA and AN enhanced the bradycardia elicited by AN stimulation but reduced the magnitude of the AN-elicited depressor response. These results provide evidence for differential modulation of the baroreceptor reflex during the defense and vigilance reactions.

AB - Electrical stimulation of the hypothalamic defense area (HDA) elicits a pressor/tachycardia response that is believed to prepare an animal for fight or flight. In contrast, electrical stimulation of the hypothalamic vigilance area (HVA) evokes a pressor/bradycardia response that is associated with the inhibition of movement. The differences in the behavioral components of these two affective response patterns suggest differential modulation of the baroreceptor reflex. The present study tested this idea by assessing the effects of electrical stimulation of the HDA and the HVA upon the bradycardia/depressor response elicited by stimulation of the aortic nerve (AN) in rabbits. Concurrent HDA and AN stimulation was observed to attenuate the AN-elicited bradycardia but enhanced the depressor response elicited by AN stimulation. In contrast, concurrent stimulation of the HVA and AN enhanced the bradycardia elicited by AN stimulation but reduced the magnitude of the AN-elicited depressor response. These results provide evidence for differential modulation of the baroreceptor reflex during the defense and vigilance reactions.

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U2 - 10.1016/0031-9384(95)02145-0

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AN - SCOPUS:0029974276

SN - 0031-9384

VL - 59

SP - 1093

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JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 6

ER -

Modulation of the baroreceptor reflex by stimulation of the hypothalamic defense and vigilance areas

Abstract

All Science Journal Classification (ASJC) codes

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