Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008

X. Z. Huang; M. A. Chahine; J. G. Frye; D. M. Cash; E. P. Lesho; D. W. Craft; L. E. Lindler; M. P. Nikolich

doi:10.1017/S0950268811002871

Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008

X. Z. Huang
, M. A. Chahine
, J. G. Frye
, D. M. Cash
, E. P. Lesho
, D. W. Craft
, L. E. Lindler
, M. P. Nikolich

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla OXA-51 gene and 40 also carried bla OXA-23 on plasmids and/or chromosome; one carried bla OXA-58 and four contained ISAbal located upstream of bla OXA-51. Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.

Original language	English (US)
Pages (from-to)	2302-2307
Number of pages	6
Journal	Epidemiology and Infection
Volume	140
Issue number	12
DOIs	https://doi.org/10.1017/S0950268811002871
State	Published - Dec 2012

All Science Journal Classification (ASJC) codes

Epidemiology
Infectious Diseases

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title = "Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008",

abstract = "Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla OXA-51 gene and 40 also carried bla OXA-23 on plasmids and/or chromosome; one carried bla OXA-58 and four contained ISAbal located upstream of bla OXA-51. Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.",

author = "Huang, \{X. Z.\} and Chahine, \{M. A.\} and Frye, \{J. G.\} and Cash, \{D. M.\} and Lesho, \{E. P.\} and Craft, \{D. W.\} and Lindler, \{L. E.\} and Nikolich, \{M. P.\}",

year = "2012",

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AU - Huang, X. Z.

AU - Chahine, M. A.

AU - Frye, J. G.

AU - Cash, D. M.

AU - Lesho, E. P.

AU - Craft, D. W.

AU - Lindler, L. E.

AU - Nikolich, M. P.

PY - 2012/12

Y1 - 2012/12

N2 - Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla OXA-51 gene and 40 also carried bla OXA-23 on plasmids and/or chromosome; one carried bla OXA-58 and four contained ISAbal located upstream of bla OXA-51. Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.

AB - Global dissemination of imipenem-resistant (IR) clones of Acinetobacter baumannii - A. calcoaceticus complex (ABC) have been frequently reported but the molecular epidemiological features of IR-ABC in military treatment facilities (MTFs) have not been described. We characterized 46 IR-ABC strains from a dataset of 298 ABC isolates collected from US service members hospitalized in different US MTFs domestically and overseas during 2003-2008. All IR strains carried the bla OXA-51 gene and 40 also carried bla OXA-23 on plasmids and/or chromosome; one carried bla OXA-58 and four contained ISAbal located upstream of bla OXA-51. Strains tended to cluster by pulsed-field gel electrophoresis profiles in time and location. Strains from two major clusters were identified as international clone I by multilocus sequence typing.

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UR - https://www.scopus.com/pages/publications/84869407392#tab=citedBy

U2 - 10.1017/S0950268811002871

DO - 10.1017/S0950268811002871

M3 - Review article

C2 - 22273504

AN - SCOPUS:84869407392

SN - 0950-2688

VL - 140

SP - 2302

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JO - Epidemiology and Infection

JF - Epidemiology and Infection

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ER -

Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008

Abstract

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