TY - JOUR
T1 - Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1
AU - Warren, James T.
AU - Chandrasekhar, Anand
AU - Kanki, John P.
AU - Rangarajan, Radha
AU - Furley, Andrew J.
AU - Kuwada, John Y.
N1 - Funding Information:
This work was supported by grants from the Paralyzed Veterans of America/Spinal Cord Research Foundation to J.T.W.J. and the Muscular Dystrophy Association to J.Y.K. We thank Dr. K. Zinn, Dr. D. Grunwald and Dr. H. Okamato for supplying cDNA libraries; and H. Suh for help with sections.
PY - 1999/2
Y1 - 1999/2
N2 - TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth promoting activity. Cell 61, 157-170). In order to examine the in vivo function of this molecule, we have cloned a zebrafish tag1-like cDNA and analyzed its expression patterns. tag1 is expressed transiently by specific subsets of neurons when they are projecting their axons or when they are migrating. The specific and dynamic pattern of expression of zebrafish tag1 is consistent with its proposed role in axon guidance and cell migration.
AB - TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth promoting activity. Cell 61, 157-170). In order to examine the in vivo function of this molecule, we have cloned a zebrafish tag1-like cDNA and analyzed its expression patterns. tag1 is expressed transiently by specific subsets of neurons when they are projecting their axons or when they are migrating. The specific and dynamic pattern of expression of zebrafish tag1 is consistent with its proposed role in axon guidance and cell migration.
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U2 - 10.1016/S0925-4773(98)00215-9
DO - 10.1016/S0925-4773(98)00215-9
M3 - Article
C2 - 10072788
AN - SCOPUS:0033020488
SN - 0925-4773
VL - 80
SP - 197
EP - 201
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 2
ER -