Abstract
Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action.
Original language | English (US) |
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Pages (from-to) | 215-222 |
Number of pages | 8 |
Journal | Nephron |
Volume | 87 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- Physiology
- Nephrology
- Physiology (medical)
- Urology