TY - GEN
T1 - Molecular mechanisms orchestrating the stem cell response to translational scaffolds
AU - Ozdemir, Tugba
AU - Higgins, Andrew M.
AU - Brown, Justin L.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/11/4
Y1 - 2015/11/4
N2 - A 2013 Perspective in Science titled 'Deconstructing Dimensionality' noted the importance of fiber morphology on cell phenotype, concluding with the statement 'Identifying the mechanisms by which cells assess the nature of their environment will advance basic cell biology and facilitate the development of synthetic matrices for specific tissue engineering applications.' Nanofibers have revolutionized scaffold-based approaches for musculoskeletal tissues; demonstrating surprising efficacy over promoting mesenchymal stem cell, MSC, differentiation down multiple musculoskeletal lineages. Understanding the fundamental mechanisms involved will allow the future design of nanofiber-based scaffolds to target a lineage with specificity. This article focuses on how three geometry sensors: focal adhesions, membrane associated vesicle stabilizing and trafficking proteins, and adherens junctions; potentially regulate MSC lineage commitment in response to bio-instructive nanofibers.
AB - A 2013 Perspective in Science titled 'Deconstructing Dimensionality' noted the importance of fiber morphology on cell phenotype, concluding with the statement 'Identifying the mechanisms by which cells assess the nature of their environment will advance basic cell biology and facilitate the development of synthetic matrices for specific tissue engineering applications.' Nanofibers have revolutionized scaffold-based approaches for musculoskeletal tissues; demonstrating surprising efficacy over promoting mesenchymal stem cell, MSC, differentiation down multiple musculoskeletal lineages. Understanding the fundamental mechanisms involved will allow the future design of nanofiber-based scaffolds to target a lineage with specificity. This article focuses on how three geometry sensors: focal adhesions, membrane associated vesicle stabilizing and trafficking proteins, and adherens junctions; potentially regulate MSC lineage commitment in response to bio-instructive nanofibers.
UR - http://www.scopus.com/inward/record.url?scp=84953242793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953242793&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2015.7318716
DO - 10.1109/EMBC.2015.7318716
M3 - Conference contribution
C2 - 26736616
AN - SCOPUS:84953242793
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1749
EP - 1752
BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Y2 - 25 August 2015 through 29 August 2015
ER -