TY - JOUR
T1 - Molecular modeling tools and approaches for CFTR and cystic fibrosis.
AU - Serohijos, Adrian W.R.
AU - Thibodeau, Patrick H.
AU - Dokholyan, Nikolay V.
PY - 2011
Y1 - 2011
N2 - Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.
AB - Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.
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U2 - 10.1007/978-1-61779-117-8_23
DO - 10.1007/978-1-61779-117-8_23
M3 - Article
C2 - 21594796
AN - SCOPUS:80052322066
SN - 1064-3745
VL - 741
SP - 347
EP - 363
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -