Molecular modeling tools and approaches for CFTR and cystic fibrosis.

Adrian W.R. Serohijos; Patrick H. Thibodeau; Nikolay V. Dokholyan

doi:10.1007/978-1-61779-117-8_23

Molecular modeling tools and approaches for CFTR and cystic fibrosis.

Adrian W.R. Serohijos
, Patrick H. Thibodeau
, Nikolay V. Dokholyan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.

Original language	English (US)
Pages (from-to)	347-363
Number of pages	17
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	741
DOIs	https://doi.org/10.1007/978-1-61779-117-8_23
State	Published - 2011

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics

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10.1007/978-1-61779-117-8_23

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abstract = "Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.",

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AB - Cystic fibrosis is a multi-faceted disease resulting from the dysfunction of the CFTR channel. Understanding the structural basis of channel function and the structural origin of the defect is imperative in the development of therapeutic strategies. Here, we describe molecular modeling tools that, in conjunction with complementary experimental tools, lead to significant findings on CFTR channel function and on the effect of the pathogenic mutant F508del.

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Molecular modeling tools and approaches for CFTR and cystic fibrosis.

Abstract

All Science Journal Classification (ASJC) codes

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