Molecular photoacoustic tomography with colloidal nanobeacons

  • Dipanjan Pan
  • , Manojit Pramanik
  • , Angana Senpan
  • , Xinmai Yang
  • , Kwang H. Song
  • , Mike J. Scott
  • , Huiying Zhang
  • , Patrick J. Gaffney
  • , Samuel A. Wickline
  • , Lihong V. Wang
  • , Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.

Original languageEnglish (US)
Pages (from-to)4170-4173
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number23
DOIs
StatePublished - May 25 2009

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry

Fingerprint

Dive into the research topics of 'Molecular photoacoustic tomography with colloidal nanobeacons'. Together they form a unique fingerprint.

Cite this