TY - JOUR
T1 - Molecular regulation of lactation
T2 - The complex and requisite roles for zinc
AU - Lee, Sooyeon
AU - Kelleher, Shannon L.
N1 - Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Lactation provides many health benefits to the nursing infant and breastfeeding mother. In order to successfully breastfeed, the mammary gland must expand and differentiate to activate numerous processes that regulate milk production and secretion. This involves a complex series of molecular, biochemical and cellular events driven largely by lactogenic hormones. Recent advances implicate zinc as a critical modulator of mammary gland function. Here, we provide an overview of our current understanding of the role and regulation of zinc in promoting proliferation, differentiation and secretion in the mammary gland during lactation, and highlight critical gaps in knowledge.
AB - Lactation provides many health benefits to the nursing infant and breastfeeding mother. In order to successfully breastfeed, the mammary gland must expand and differentiate to activate numerous processes that regulate milk production and secretion. This involves a complex series of molecular, biochemical and cellular events driven largely by lactogenic hormones. Recent advances implicate zinc as a critical modulator of mammary gland function. Here, we provide an overview of our current understanding of the role and regulation of zinc in promoting proliferation, differentiation and secretion in the mammary gland during lactation, and highlight critical gaps in knowledge.
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U2 - 10.1016/j.abb.2016.04.002
DO - 10.1016/j.abb.2016.04.002
M3 - Article
C2 - 27059852
AN - SCOPUS:84978924448
SN - 0003-9861
VL - 611
SP - 86
EP - 92
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -