TY - JOUR
T1 - Molecular regulation of MCU
T2 - Implications in physiology and disease
AU - Nemani, Neeharika
AU - Shanmughapriya, Santhanam
AU - Madesh, Muniswamy
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/9
Y1 - 2018/9
N2 - Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics, intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into the mitochondria occurs due to the highly negative membrane potential (ΔΨ m ) through a selective inward rectifying MCU channel. In addition to being regulated by various mitochondrial matrix resident proteins such as MICUs, MCUb, MCUR1 and EMRE, the channel is transcriptionally regulated by upstream Ca 2+ cascade, post transnational modification and by divalent cations. The mode of regulation either inhibits or enhances MCU channel activity and thus regulates mitochondrial metabolism and cell fate.
AB - Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics, intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into the mitochondria occurs due to the highly negative membrane potential (ΔΨ m ) through a selective inward rectifying MCU channel. In addition to being regulated by various mitochondrial matrix resident proteins such as MICUs, MCUb, MCUR1 and EMRE, the channel is transcriptionally regulated by upstream Ca 2+ cascade, post transnational modification and by divalent cations. The mode of regulation either inhibits or enhances MCU channel activity and thus regulates mitochondrial metabolism and cell fate.
UR - https://www.scopus.com/pages/publications/85049352289
UR - https://www.scopus.com/pages/publications/85049352289#tab=citedBy
U2 - 10.1016/j.ceca.2018.06.006
DO - 10.1016/j.ceca.2018.06.006
M3 - Review article
C2 - 29980025
AN - SCOPUS:85049352289
SN - 0143-4160
VL - 74
SP - 86
EP - 93
JO - Cell Calcium
JF - Cell Calcium
ER -