Abstract
Efficient downsizing of peptides: By combination of two orthogonal "conformation-based" and "sequence-based" libraries, the cyclic pentapeptide cyclo-(-L-Nal1-Gly2-D-Tyr3-L-Arg4-L-Arg5-) (Nal = L-3-(2-naphthyl)alanine; see overlay of the five lowest energy structures), which exhibited strong CXCR4 antagonistm (IC50 = 4 nM) comparable to that of a 14-residue lead compound, T140, was discovered.
Original language | English (US) |
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Pages (from-to) | 3251-3253 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 42 |
Issue number | 28 |
DOIs | |
State | Published - Jul 28 2003 |
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry