Molecularly Regulated Reversible DNA Polymerization

Niancao Chen, Xuechen Shi, Yong Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Natural polymers are synthesized and decomposed under physiological conditions. However, it is challenging to develop synthetic polymers whose formation and reversibility can be both controlled under physiological conditions. Here we show that both linear and branched DNA polymers can be synthesized via molecular hybridization in aqueous solutions, on the particle surface, and in the extracellular matrix (ECM) without the involvement of any harsh conditions. More importantly, these polymers can be effectively reversed to dissociate under the control of molecular triggers. Since nucleic acids can be conjugated with various molecules or materials, we anticipate that molecularly regulated reversible DNA polymerization holds potential for broad biological and biomedical applications. Reversible DNA polymerization: Linear and branched DNA polymers were synthesized and decomposed using molecular triggers under physiological conditions (see picture). The polymerization mechanism is based on the well-known hybridization chain reaction.

Original languageEnglish (US)
Pages (from-to)6657-6661
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number23
StatePublished - Jun 1 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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