Molecule specific imaging in biology: What are the challenges and the important applications?

A. G. Ewing

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


It is becoming clear that mass spectrometry is a powerful tool for the analysis and imaging of complex organic and biological systems. The discussion session "Meeting the Challenge of Molecule Specific Analysis and Imaging in Organic and Bio-Systems" will attempt to illustrate the challenges to be met in mass spectral imaging and analysis of biological samples. Some of these challenges will be discussed here including the issues of sensitivity needed to obtain high resolution images at the cellular and sub-cellular level, information that can be obtained with alternative techniques and where will they be better versus when SIMS will be better suited to the need, and finally the need for depth profiling and mechanisms to achieve this goal for cellular samples.

Original languageEnglish (US)
Pages (from-to)6821-6826
Number of pages6
JournalApplied Surface Science
Issue number19
StatePublished - Jul 30 2006

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films


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