TY - JOUR
T1 - Monitored daily ambulatory activity, inflammation, and oxidative stress in patients with claudication
AU - Gardner, Andrew W.
AU - Parker, Donald E.
AU - Montgomery, Polly S.
AU - Blevins, Steve M.
AU - Teague, April M.
AU - Casanegra, Ana I.
PY - 2014/7
Y1 - 2014/7
N2 - We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (P <.001), total daily ambulatory time (P <.01), peak activity index (P <.01), daily average cadence (P <.05), and the maximum cadences for 60 minutes (P <.05), 30 minutes (P <.05), 20 minutes (P <.05), and 5 minutes (P <.01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures (P >.05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.
AB - We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides (P <.001), total daily ambulatory time (P <.01), peak activity index (P <.01), daily average cadence (P <.05), and the maximum cadences for 60 minutes (P <.05), 30 minutes (P <.05), 20 minutes (P <.05), and 5 minutes (P <.01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures (P >.05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.
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U2 - 10.1177/0003319713489769
DO - 10.1177/0003319713489769
M3 - Article
C2 - 23695338
AN - SCOPUS:84902199688
SN - 0003-3197
VL - 65
SP - 491
EP - 496
JO - Angiology
JF - Angiology
IS - 6
ER -