Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

Jiayin Zhang; Hua Zhao; Xitian Zhang; Xuanzhang Wang; Hong Gao; Zhiguo Zhang; Wenwu Cao

doi:10.1021/jp410993a

Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

Jiayin Zhang, Hua Zhao, Xitian Zhang, Xuanzhang Wang, Hong Gao, Zhiguo Zhang, Wenwu Cao

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF₄: Yb³⁺, Tm³⁺ upconversion nanoparticles are investigated. The ratio of I₈₀₀ to I₄₇₀, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm³⁺ doping concentration in NaYF₄: Yb³⁺, Tm³⁺ nanoparticles, can reach as high as 757 at 4% Tm³⁺. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10^-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.

Original language	English (US)
Pages (from-to)	2820-2825
Number of pages	6
Journal	Journal of Physical Chemistry C
Volume	118
Issue number	5
DOIs	https://doi.org/10.1021/jp410993a
State	Published - Feb 6 2014

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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title = "Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging",

abstract = "To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4% Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.",

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T1 - Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

AU - Zhang, Jiayin

AU - Zhao, Hua

AU - Zhang, Xitian

AU - Wang, Xuanzhang

AU - Gao, Hong

AU - Zhang, Zhiguo

AU - Cao, Wenwu

PY - 2014/2/6

Y1 - 2014/2/6

N2 - To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4% Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.

AB - To develop a fluorescent bioprobe for high-contrast deep tissue fluorescence imaging, monochromatic 800 nm upconversion emissions based on NaYF4: Yb3+, Tm3+ upconversion nanoparticles are investigated. The ratio of I800 to I470, which is used to describe the monochromaticity, showing exponential growth with the increase of Tm3+ doping concentration in NaYF4: Yb3+, Tm3+ nanoparticles, can reach as high as 757 at 4% Tm3+. At such a doping level, the absolute quantum efficiency can reach 3.9 × 10-3 as measured by a calibrated integrating sphere, which is sufficient for fluorescence imaging. High-contrast fluorescence phantom imaging was obtained by adjusting monochromaticity of 800 nm upconversion emission under the excitation of a 980 nm diode laser.

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Monochromatic Near-infrared to near-infrared upconversion nanoparticles for high-contrast fluorescence imaging

Abstract

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