TY - JOUR
T1 - Mononuclear phagocyte diversity in the intestine
AU - Bogunovic, Milena
AU - Mortha, Arthur
AU - Muller, Paul Andrew
AU - Merad, Miriam
N1 - Funding Information:
Acknowledgments We would like to thank M. C. Berin for her helpful comments. M.B. is supported by a career development award from the Crohn’s and Colitis Foundation of America and a primary caregiver technical assistance supplement from the National Institute of Allergy and Infectious Diseases. A.M. is supported by a fellowship from the German Research Foundation (DFG), MO 2380/1-1:1. M.M. is supported by the National Institutes of Health grants HL086899, AI095611 and CA154947.
PY - 2012/12
Y1 - 2012/12
N2 - Present in all organs, mononuclear phagocytes consist of a heterogeneous population of hematopoietic cells whose main role is to ensure tissue homeostasis through their ability to scavenge cell debris, promote tissue repair and maintain tolerance to self-antigens while simultaneously inducing innate and adaptive immune responses against foreign antigens that breach the tissue. The intestinal mucosa is particularly exposed to foreign antigen, through constant exposure to high loads of commensal bacteria and dietary antigens as well as providing a site of entry for viral and bacterial pathogens. The molecular mechanisms that control the intestinal ability to distinguish between innocuous and dangerous antigens remains poorly understood although it is clear that mononuclear phagocytes play a key role in this process. This review highlights recent advances in our understanding of heterogeneous origin of the mononuclear phagocytes that inhabit the intestinal mucosa and discusses how developmental diversity allows for functional diversity to ensure intestinal integrity.
AB - Present in all organs, mononuclear phagocytes consist of a heterogeneous population of hematopoietic cells whose main role is to ensure tissue homeostasis through their ability to scavenge cell debris, promote tissue repair and maintain tolerance to self-antigens while simultaneously inducing innate and adaptive immune responses against foreign antigens that breach the tissue. The intestinal mucosa is particularly exposed to foreign antigen, through constant exposure to high loads of commensal bacteria and dietary antigens as well as providing a site of entry for viral and bacterial pathogens. The molecular mechanisms that control the intestinal ability to distinguish between innocuous and dangerous antigens remains poorly understood although it is clear that mononuclear phagocytes play a key role in this process. This review highlights recent advances in our understanding of heterogeneous origin of the mononuclear phagocytes that inhabit the intestinal mucosa and discusses how developmental diversity allows for functional diversity to ensure intestinal integrity.
UR - http://www.scopus.com/inward/record.url?scp=84867856948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867856948&partnerID=8YFLogxK
U2 - 10.1007/s12026-012-8323-5
DO - 10.1007/s12026-012-8323-5
M3 - Review article
C2 - 22562804
AN - SCOPUS:84867856948
SN - 0257-277X
VL - 54
SP - 37
EP - 49
JO - Immunologic Research
JF - Immunologic Research
IS - 1-3
ER -