TY - JOUR
T1 - More than meets the eye? Factors that affect target selection by plant miRNAs and heterochromatic siRNAs
AU - Wang, Feng
AU - Polydore, Seth
AU - Axtell, Michael J.
N1 - Funding Information:
We thank Andrzej Wierzbicki for discussion of this manuscript. Seth Polydore is supported by the NIH-PSU funded Computation, Bioinformatics and Statistics (CBIOS) Predoctoral Training Program ( 1T32GM102057-0A1 ). This work was supported by NSF award 1121438 to MJA.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - MicroRNAs, which target mRNAs for post-transcriptional regulation, and heterochromatic siRNAs, which target chromatin causing DNA methylation, make up the majority of the endogenous regulatory small RNA pool in most plant specimens. They both function to guide Argonaute proteins to targeted nucleic acids on the basis of complementarity. Recent work on plant miRNA-target interactions has clarified the general ''rules' of complementarity, while also providing several intriguing exceptions to these rules. In addition, emerging evidence suggests that several factors besides miRNA-target complementarity affect plant miRNA function. For heterochromatic siRNAs, recent work has made progress towards comprehensively identifying potential target regions, but numerous fundamental questions remain to be answered.
AB - MicroRNAs, which target mRNAs for post-transcriptional regulation, and heterochromatic siRNAs, which target chromatin causing DNA methylation, make up the majority of the endogenous regulatory small RNA pool in most plant specimens. They both function to guide Argonaute proteins to targeted nucleic acids on the basis of complementarity. Recent work on plant miRNA-target interactions has clarified the general ''rules' of complementarity, while also providing several intriguing exceptions to these rules. In addition, emerging evidence suggests that several factors besides miRNA-target complementarity affect plant miRNA function. For heterochromatic siRNAs, recent work has made progress towards comprehensively identifying potential target regions, but numerous fundamental questions remain to be answered.
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U2 - 10.1016/j.pbi.2015.06.012
DO - 10.1016/j.pbi.2015.06.012
M3 - Review article
C2 - 26246393
AN - SCOPUS:84938337208
SN - 1369-5266
VL - 27
SP - 118
EP - 124
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
ER -