TY - JOUR
T1 - Mosquitocidal vaccines
T2 - a neglected addition to malaria and dengue control strategies
AU - Billingsley, Peter F.
AU - Foy, Brian
AU - Rasgon, Jason L.
N1 - Funding Information:
P.F.B. was funded by the European Commission during the work leading up to this article; the views presented here are those of the author, not of Sanaria Inc. B.D.F. acknowledges support on this paper from National Institutes of Health (NIH) contract N01 AI25489, and J.L.R. was funded by the Johns Hopkins Malaria Research Institute and the NIH.
PY - 2008/9
Y1 - 2008/9
N2 - The transmission of vector-borne diseases is dependent upon the ability of the vector to survive for longer than the period of development of the pathogen within the vector. One means of reducing mosquito lifespan, and thereby reducing their capacity to transmit diseases, is to target mosquitoes with vaccines. Here, the principle behind mosquitocidal vaccines is described, their potential impact in malaria and dengue control is modeled and the current research that could make these vaccines a reality is reviewed. Mosquito genome data, combined with modern molecular techniques, can be exploited to overcome the limited advances in this field. Given the large potential benefit to vector-borne disease control, research into the development of mosquitocidal vaccines deserves a high profile.
AB - The transmission of vector-borne diseases is dependent upon the ability of the vector to survive for longer than the period of development of the pathogen within the vector. One means of reducing mosquito lifespan, and thereby reducing their capacity to transmit diseases, is to target mosquitoes with vaccines. Here, the principle behind mosquitocidal vaccines is described, their potential impact in malaria and dengue control is modeled and the current research that could make these vaccines a reality is reviewed. Mosquito genome data, combined with modern molecular techniques, can be exploited to overcome the limited advances in this field. Given the large potential benefit to vector-borne disease control, research into the development of mosquitocidal vaccines deserves a high profile.
UR - http://www.scopus.com/inward/record.url?scp=49449097038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49449097038&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2008.06.003
DO - 10.1016/j.pt.2008.06.003
M3 - Article
C2 - 18678529
AN - SCOPUS:49449097038
SN - 1471-4922
VL - 24
SP - 396
EP - 400
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 9
ER -
