TY - JOUR
T1 - MRI of articular cartilage in OA
T2 - novel pulse sequences and compositional/functional markers
AU - Gold, Garry E.
AU - Burstein, Deborah
AU - Dardzinski, Bernard
AU - Lang, Phillip
AU - Boada, Fernando
AU - Mosher, Timothy
N1 - Funding Information:
The authors would like to acknowledge the support of NIH grants AR46904, AR47179, AR47784, AR47363, EB002524, EB 005790, and AR-42773. We would also like to acknowledge the generous support of the Whitaker Foundation and Arthritis Foundation.
PY - 2006
Y1 - 2006
N2 - Osteoarthritis (OA) is a leading cause of disability worldwide. Magnetic resonance imaging (MRI), with its unique ability to image and characterize soft tissue non-invasively, has proven valuable in assessing cartilage in OA. The development of new, fast imaging methods with high contrast show promise to improve the magnetic resonance (MR) evaluation of this disease. In addition to morphologic MRI methods, MRI contrast mechanisms under development may reveal detailed information about the physiology of cartilage. It is anticipated that these and other MRI techniques will play an increasingly important role in assessing the success or failure of therapies for OA. On December 5 and 6, 2002, OMERACT (Outcome Measures in Rheumatology Clinical Trials) and OARSI (Osteoarthritis Research Society International) held a workshop in Bethesda, MD aiming at providing a state-of-the-art review of imaging outcome measures for OA of the knee to help guide scientists and pharmaceutical companies in the use of MRI in multi-site studies of OA. Applications of MRI were initially reviewed by a multidisciplinary, international panel of expert scientists and physicians from academia, the pharmaceutical industry and regulatory agencies. The findings of the panel were then presented to a wider group of participants for open discussion. The following report summarizes the results of these discussions with respect to novel MRI pulse sequences for evaluating articular cartilage of the knee in OA and notes any additional advances that have been made since.
AB - Osteoarthritis (OA) is a leading cause of disability worldwide. Magnetic resonance imaging (MRI), with its unique ability to image and characterize soft tissue non-invasively, has proven valuable in assessing cartilage in OA. The development of new, fast imaging methods with high contrast show promise to improve the magnetic resonance (MR) evaluation of this disease. In addition to morphologic MRI methods, MRI contrast mechanisms under development may reveal detailed information about the physiology of cartilage. It is anticipated that these and other MRI techniques will play an increasingly important role in assessing the success or failure of therapies for OA. On December 5 and 6, 2002, OMERACT (Outcome Measures in Rheumatology Clinical Trials) and OARSI (Osteoarthritis Research Society International) held a workshop in Bethesda, MD aiming at providing a state-of-the-art review of imaging outcome measures for OA of the knee to help guide scientists and pharmaceutical companies in the use of MRI in multi-site studies of OA. Applications of MRI were initially reviewed by a multidisciplinary, international panel of expert scientists and physicians from academia, the pharmaceutical industry and regulatory agencies. The findings of the panel were then presented to a wider group of participants for open discussion. The following report summarizes the results of these discussions with respect to novel MRI pulse sequences for evaluating articular cartilage of the knee in OA and notes any additional advances that have been made since.
UR - http://www.scopus.com/inward/record.url?scp=33745178138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745178138&partnerID=8YFLogxK
U2 - 10.1016/j.joca.2006.03.010
DO - 10.1016/j.joca.2006.03.010
M3 - Article
C2 - 16716605
AN - SCOPUS:33745178138
SN - 1063-4584
VL - 14
SP - 76
EP - 86
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - SUPPL. 1
ER -