Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Audrey J. Jenkins; C. Max Lang; Lynn R. Budgeon; Nancy M. Cladel; Cynthia A. Reed; Danny R. Welch; Neil D. Christensen

doi:10.1016/S0168-1702(03)00071-6

Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Audrey J. Jenkins, C. Max Lang, Lynn R. Budgeon, Nancy M. Cladel, Cynthia A. Reed, Danny R. Welch, Neil D. Christensen

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40_Hershey or HPV-40_H) productively infected genital tissues. In this study, HPV-40_H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40_H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40_H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40_H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

Original language	English (US)
Pages (from-to)	109-114
Number of pages	6
Journal	Virus Research
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0168-1702(03)00071-6
State	Published - May 1 2003

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0168-1702(03)00071-6

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title = "Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice",

abstract = "HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.",

author = "Jenkins, {Audrey J.} and Lang, {C. Max} and Budgeon, {Lynn R.} and Cladel, {Nancy M.} and Reed, {Cynthia A.} and Welch, {Danny R.} and Christensen, {Neil D.}",

note = "Funding Information: This work was supported by PHS grants RO1 CA47622 from the NCI, NIH, T32 RR07066 from the NCRR, NIH, and the Jake Gittlen Memorial Golf tournament.",

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doi = "10.1016/S0168-1702(03)00071-6",

language = "English (US)",

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pages = "109--114",

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T1 - Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

AU - Jenkins, Audrey J.

AU - Lang, C. Max

AU - Budgeon, Lynn R.

AU - Cladel, Nancy M.

AU - Reed, Cynthia A.

AU - Welch, Danny R.

AU - Christensen, Neil D.

N1 - Funding Information: This work was supported by PHS grants RO1 CA47622 from the NCI, NIH, T32 RR07066 from the NCRR, NIH, and the Jake Gittlen Memorial Golf tournament.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

AB - HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

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SN - 0168-1702

VL - 93

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Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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