Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Audrey J. Jenkins; C. Max Lang; Lynn R. Budgeon; Nancy M. Cladel; Cynthia A. Reed; Danny R. Welch; Neil D. Christensen

doi:10.1016/S0168-1702(03)00071-6

Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Audrey J. Jenkins
, C. Max Lang
, Lynn R. Budgeon
, Nancy M. Cladel
, Cynthia A. Reed
, Danny R. Welch
, Neil D. Christensen

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40_Hershey or HPV-40_H) productively infected genital tissues. In this study, HPV-40_H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40_H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40_H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40_H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

Original language	English (US)
Pages (from-to)	109-114
Number of pages	6
Journal	Virus Research
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0168-1702(03)00071-6
State	Published - May 1 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases
Cancer Research

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10.1016/S0168-1702(03)00071-6

Cite this

@article{79ed9d543cde401c8d75a34d676e7f6a,

title = "Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice",

abstract = "HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.",

author = "Jenkins, \{Audrey J.\} and Lang, \{C. Max\} and Budgeon, \{Lynn R.\} and Cladel, \{Nancy M.\} and Reed, \{Cynthia A.\} and Welch, \{Danny R.\} and Christensen, \{Neil D.\}",

note = "Funding Information: This work was supported by PHS grants RO1 CA47622 from the NCI, NIH, T32 RR07066 from the NCRR, NIH, and the Jake Gittlen Memorial Golf tournament.",

year = "2003",

month = may,

day = "1",

doi = "10.1016/S0168-1702(03)00071-6",

language = "English (US)",

volume = "93",

pages = "109--114",

journal = "Virus Research",

issn = "0168-1702",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

AU - Jenkins, Audrey J.

AU - Lang, C. Max

AU - Budgeon, Lynn R.

AU - Cladel, Nancy M.

AU - Reed, Cynthia A.

AU - Welch, Danny R.

AU - Christensen, Neil D.

N1 - Funding Information: This work was supported by PHS grants RO1 CA47622 from the NCI, NIH, T32 RR07066 from the NCRR, NIH, and the Jake Gittlen Memorial Golf tournament.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

AB - HPV-40 is a rare HPV type that has been detected only in genital mucosal tissues. This HPV type is very closely related to HPV-7, which has a predominantly cutaneous tissue tropism. We have shown, previously, that an isolate of HPV-40 (described here as HPV-40Hershey or HPV-40H) productively infected genital tissues. In this study, HPV-40H was tested for productive infection of cutaneous tissue. Fetal hand skin fragments were incubated with infectious HPV-40H and implanted subrenally into athymic mice. After 120 days, xenografts showed morphological changes consistent with HPV-40H infection and were HPV-40 DNA in situ positive and capsid antigen positive. The results demonstrated that hand skin can support HPV-40H infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues.

UR - https://www.scopus.com/pages/publications/0037406596

UR - https://www.scopus.com/pages/publications/0037406596#tab=citedBy

U2 - 10.1016/S0168-1702(03)00071-6

DO - 10.1016/S0168-1702(03)00071-6

M3 - Article

C2 - 12727348

AN - SCOPUS:0037406596

SN - 0168-1702

VL - 93

SP - 109

EP - 114

JO - Virus Research

JF - Virus Research

IS - 1

ER -

Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice

Abstract

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