Multicenter clinical performance evaluation of BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus

J. Jeremiah Bell; Evan J. Anderson; Wallace Greene; José R. Romero; Moheet Merchant; Rangaraj Selvarangan

doi:10.1016/j.jcv.2014.05.020

Multicenter clinical performance evaluation of BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus

J. Jeremiah Bell, Evan J. Anderson, Wallace Greene, José R. Romero, Moheet Merchant, Rangaraj Selvarangan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children. Objective: To evaluate the performance of BD Veritor™ System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients. Study design: A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor™ System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse). Results: 440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects. <. 20 years of age were collected and tested using the BD Veritor™ System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor™ System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively. Conclusion: Overall, the BD Veritor™ System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.

Original language	English (US)
Pages (from-to)	113-117
Number of pages	5
Journal	Journal of Clinical Virology
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/j.jcv.2014.05.020
State	Published - Sep 2014

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcv.2014.05.020

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title = "Multicenter clinical performance evaluation of BD Veritor{\texttrademark} System for Rapid Detection of Respiratory Syncytial Virus",

abstract = "Background: BD Veritor{\texttrademark} System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children. Objective: To evaluate the performance of BD Veritor{\texttrademark} System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients. Study design: A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor{\texttrademark} System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse). Results: 440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects. <. 20 years of age were collected and tested using the BD Veritor{\texttrademark} System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor{\texttrademark} System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively. Conclusion: Overall, the BD Veritor{\texttrademark} System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.",

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AU - Selvarangan, Rangaraj

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N2 - Background: BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children. Objective: To evaluate the performance of BD Veritor™ System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients. Study design: A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor™ System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse). Results: 440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects. <. 20 years of age were collected and tested using the BD Veritor™ System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor™ System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively. Conclusion: Overall, the BD Veritor™ System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.

AB - Background: BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus (RSV) is a new-generation lateral flow immunochromatographic assay for objective detection of RSV in respiratory specimens from children. Objective: To evaluate the performance of BD Veritor™ System for Rapid Detection of RSV in respiratory specimens collected from pediatric patients. Study design: A prospective, multicenter clinical trial was undertaken at five study sites representing geographically diverse regions of the U.S. to assess the performance of the BD Veritor™ System for Rapid Detection of RSV in comparison to R-mix shell vial culture and ProFlu+ reverse transcription-PCR assay (Gen-Probe/Prodesse). Results: 440 nasopharyngeal washes/aspirates (NPW/A) and 706 nasopharyngeal swab (NPS) specimens from U.S. subjects. <. 20 years of age were collected and tested using the BD Veritor™ System and compared with shell vial culture and real-time RT-PCR results. Analysis of the data indicates the overall sensitivity and specificity for BD Veritor™ System for all sample types combined was 90% and 97.0% versus shell vial culture and 75.5% and 98.7% versus RT-PCR respectively. Conclusion: Overall, the BD Veritor™ System for the Rapid Detection of RSV performed well when compared to both viral cell culture and RT-PCR in children.

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Multicenter clinical performance evaluation of BD Veritor™ System for Rapid Detection of Respiratory Syncytial Virus

Abstract

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