Multicenter trial of naloxone in alzheimer's disease

V. W. Henderson, E. Roberts, C. Wimer, E. L. Bardolph, H. C. Chui, A. R. Damasio, P. J. Eslinger, M. F. Folstein, L. S. Schneider, E. L. Teng, L. E. Tune, L. P. Weiner, P. J. Whitehouse

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In a double‐blind, placebo‐controlled, crossover study of intravenously administered naloxone hydrochloride, 54 subjects with clinically ascertained Alzheimer's disease tested at three university centers showed no significant improvement in neuropsychological performance after 1‐mg or 10‐mg doses; 15 patients at 1 center were similarly unimproved after receiving 30 mg naloxone (single blind). Findings fail to support claims that naloxone monotherapy ameliorates cognitive impairments of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)404-406
Number of pages3
JournalAnnals of Neurology
Issue number4
StatePublished - Apr 1989

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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