Multidisciplinary Management and Radiotherapy Recommendations for Clinically and Pathologically Node-positive Bladder Cancer

Bhanu Prasad Venkatesulu, Stanley L. Liauw, Monika Joshi, Brian C. Baumann, Ryan Yoo, Morgan Roupret, Ananya Choudhury, Jason A. Efstathiou, Vedang Murthy, Paul Sargos, Abhishek A. Solanki

Research output: Contribution to journalReview articlepeer-review

Abstract

There are limited data regarding the optimal management of patients with pelvic node-positive, but non-metastatic, bladder cancer. Increasing data demonstrate that this is a distinct clinical entity with outcomes bridging between bladder-confined muscle-invasive bladder cancer and metastatic advanced bladder cancer. Guidelines and staging systems have formalized the need to incorporate the unique considerations of management of pelvic node-positive bladder cancer. However, there remains an absence of a definite standard of care. Treatment options include systemic therapy alone, neoadjuvant chemotherapy followed by radical cystectomy, or bladder-preserving trimodality therapy. Furthermore, ongoing studies aim to determine the benefit of incorporating immunotherapy into these treatment paradigms. In this review article, we will discuss the key considerations for management of patients with pelvic node-positive bladder cancer.

Original languageEnglish (US)
Pages (from-to)35-50
Number of pages16
JournalSeminars in Radiation Oncology
Volume33
Issue number1
DOIs
StatePublished - Jan 2023

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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