Multifaceted Role of Insulin-Like Growth Factors and Mammalian Target of Rapamycin in Skeletal Muscle

Robert A. Frost, Charles H. Lang

    Research output: Contribution to journalReview articlepeer-review

    29 Scopus citations

    Abstract

    This review describes the current literature on the interaction between insulin-like growth factors, endocrine hormones, and branched-chain amino acids on muscle physiology in healthy young individuals and during select pathologic conditions. Emphasis is placed on the mechanism by which physical and hormonal signals are transduced at the cellular level to either grow or atrophy skeletal muscle. The key role of the mammalian target of rapamycin and its ability to respond to hypertrophic and atrophic signals informs our understanding how a combination of physical, nutritional, and pharmacologic therapies may be used in tandem to prevent or ameliorate reductions in muscle mass.

    Original languageEnglish (US)
    Pages (from-to)297-322
    Number of pages26
    JournalEndocrinology and Metabolism Clinics of North America
    Volume41
    Issue number2
    DOIs
    StatePublished - Jun 2012

    All Science Journal Classification (ASJC) codes

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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