TY - JOUR
T1 - Multimorbidity of overweight and obesity alongside anxiety and depressive disorders in individuals with spinal cord injury
AU - Graupensperger, Scott
AU - Sweet, Shane N.
AU - Evans, M. Blair
N1 - Funding Information:
Funding The project described was supported by NIH National Center for Advancing Translational Sciences (award TL1 TR002016). SNS is supported by a Junior 1 salary award by the Fonds de Recherche du Quebec – Santé. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or FRQS.
Funding Information:
Contributors. The authors wish to thank Dr. Jim Pawelczyk and Dr. Tom Lloyd at the Penn State University’s Clinical and Translational Science Institute for guidance in using the i2b2 database tool and for early input on the design of the present study. Funding The project described was supported by NIH National Center for Advancing Translational Sciences (award TL1 TR002016). SNS is supported by a Junior 1 salary award by the Fonds de Recherche du Quebec–Santé. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or FRQS. Declaration of interest None. Conflicts of interest Authors have no conflict of interests to declare.
Publisher Copyright:
© The Academy of Spinal Cord Injury Professionals, Inc. 2018.
PY - 2021
Y1 - 2021
N2 - Objective: To compare the prevalence of anxiety/depression and overweight/obesity (Aim 1) and the multimorbidity of these conditions (Aim 2) in a sample of adults with and without spinal cord injury (SCI). Aim 3 was to examine whether overweight/obese individuals with SCI differ on the prevalence of anxiety/depressive disorders compared to non-overweight/obese individuals with SCI. Design: Retrospective cohort study. Participants: Individuals ≥16 years old who had patient encounters between January 1, 2011, and February 28, 2018. In total, 761 598 individuals were included, of which 3136 had SCI. Main Outcome Measures: Individuals were identified as diagnosed with SCI, anxiety and/or depressive disorders, and overweight/obesity using the International Classification of Diseases. Results: Age-adjusted odds ratios (ORs) were calculated using logistic regression. In contrast to non-SCI individuals, those with SCI had increased odds of anxiety disorders (OR: 3.58, 95% CI [3.29–3.90]), depressive disorders (OR: 4.33, 95% CI [3.95–4.74]), and overweight/obesity (OR: 3.08, 95% CI [2.80–3.38]). Pertaining to multimorbidity, individuals with SCI had increased odds of having overweight/obesity alongside anxiety disorders (OR: 4.30, 95% CI [3.71–4.98]) and overweight/obesity alongside depressive disorders (OR: 4.69, 95% CI [4.01–5.47]) compared to those without SCI. Individuals with SCI who were diagnosed as overweight/obese had increased odds of having anxiety disorders (OR: 2.54, 95% CI [2.06–3.13]), and depressive disorders (OR: 2.70, 95% CI [2.18–3.36]), relative to non-overweight/obese individuals with SCI. Conclusions: This work is among the first to find evidence that individuals with SCI are at heightened odds of overweight/obesity alongside anxiety and/or depressive disorders. This early work holds clinical implications for treating these interrelated comorbidities in SCI.
AB - Objective: To compare the prevalence of anxiety/depression and overweight/obesity (Aim 1) and the multimorbidity of these conditions (Aim 2) in a sample of adults with and without spinal cord injury (SCI). Aim 3 was to examine whether overweight/obese individuals with SCI differ on the prevalence of anxiety/depressive disorders compared to non-overweight/obese individuals with SCI. Design: Retrospective cohort study. Participants: Individuals ≥16 years old who had patient encounters between January 1, 2011, and February 28, 2018. In total, 761 598 individuals were included, of which 3136 had SCI. Main Outcome Measures: Individuals were identified as diagnosed with SCI, anxiety and/or depressive disorders, and overweight/obesity using the International Classification of Diseases. Results: Age-adjusted odds ratios (ORs) were calculated using logistic regression. In contrast to non-SCI individuals, those with SCI had increased odds of anxiety disorders (OR: 3.58, 95% CI [3.29–3.90]), depressive disorders (OR: 4.33, 95% CI [3.95–4.74]), and overweight/obesity (OR: 3.08, 95% CI [2.80–3.38]). Pertaining to multimorbidity, individuals with SCI had increased odds of having overweight/obesity alongside anxiety disorders (OR: 4.30, 95% CI [3.71–4.98]) and overweight/obesity alongside depressive disorders (OR: 4.69, 95% CI [4.01–5.47]) compared to those without SCI. Individuals with SCI who were diagnosed as overweight/obese had increased odds of having anxiety disorders (OR: 2.54, 95% CI [2.06–3.13]), and depressive disorders (OR: 2.70, 95% CI [2.18–3.36]), relative to non-overweight/obese individuals with SCI. Conclusions: This work is among the first to find evidence that individuals with SCI are at heightened odds of overweight/obesity alongside anxiety and/or depressive disorders. This early work holds clinical implications for treating these interrelated comorbidities in SCI.
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U2 - 10.1080/10790268.2018.1507801
DO - 10.1080/10790268.2018.1507801
M3 - Article
C2 - 30183556
AN - SCOPUS:85053255902
SN - 1079-0268
VL - 44
SP - 992
EP - 1000
JO - Journal of Spinal Cord Medicine
JF - Journal of Spinal Cord Medicine
IS - 6
ER -