Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

Pedro A.B. Pereira, Drupad K. Trivedi, Justin Silverman, Ilhan Cem Duru, Lars Paulin, Petri Auvinen, Filip Scheperjans

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.

Original languageEnglish (US)
Article number39
Journalnpj Parkinson's Disease
Volume8
Issue number1
DOIs
StatePublished - Dec 2022

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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