Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

Pedro A.B. Pereira; Drupad K. Trivedi; Justin Silverman; Ilhan Cem Duru; Lars Paulin; Petri Auvinen; Filip Scheperjans

doi:10.1038/s41531-022-00300-3

Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

Pedro A.B. Pereira, Drupad K. Trivedi, Justin Silverman, Ilhan Cem Duru, Lars Paulin, Petri Auvinen, Filip Scheperjans

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.

Original language	English (US)
Article number	39
Journal	npj Parkinson's Disease
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41531-022-00300-3
State	Published - Dec 2022

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

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abstract = "We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson{\textquoteright}s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.",

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AU - Pereira, Pedro A.B.

AU - Trivedi, Drupad K.

AU - Silverman, Justin

AU - Duru, Ilhan Cem

AU - Paulin, Lars

AU - Auvinen, Petri

AU - Scheperjans, Filip

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AB - We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.

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Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease

Abstract

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