TY - JOUR
T1 - Multiple pregnancies conceived with intrauterine insemination during superovulation
T2 - An evaluation of clinical characteristics and monitored parameters of conception cycles
AU - Dodson, William C.
AU - Hughes, Claude L.
AU - Haney, A. F.
PY - 1988
Y1 - 1988
N2 - The use of human menopausal gonadotropins to induce superovulation in conjunction with intrauterine insemination as treatment for infertility is associated with an increased incidence of multiple gestation. Identification of clinical characteristics and/or monitored parameters of the stimulation cycles highly associated with multiple gestation would enable cancellation of these cycles. We retrospectively evaluated the clinical profiles and conception cycle characteristics of 48 infertile women undergoing the induction of superovulation and intrauterine insemination. We compared 14 of these women who conceived multiple gestations (eight twins and six triplets) with 34 who conceived singleton gestations. We found no differences between the groups in age, parity, cause or duration of infertility, duration or amount of human menopausal gonadotropin administration, serum estradiol concentrations on the day of human chorionic gonadotropin injection, number of preovulatory-sized follicles, or number of motile sperm inseminated. We conclude that neither the patients' clinical characteristics nor the parameters evaluated in monitoring human menopausal gonadotropin cycles provide information helpful in predicting which superovulation cycles will result in multiple pregnancy.
AB - The use of human menopausal gonadotropins to induce superovulation in conjunction with intrauterine insemination as treatment for infertility is associated with an increased incidence of multiple gestation. Identification of clinical characteristics and/or monitored parameters of the stimulation cycles highly associated with multiple gestation would enable cancellation of these cycles. We retrospectively evaluated the clinical profiles and conception cycle characteristics of 48 infertile women undergoing the induction of superovulation and intrauterine insemination. We compared 14 of these women who conceived multiple gestations (eight twins and six triplets) with 34 who conceived singleton gestations. We found no differences between the groups in age, parity, cause or duration of infertility, duration or amount of human menopausal gonadotropin administration, serum estradiol concentrations on the day of human chorionic gonadotropin injection, number of preovulatory-sized follicles, or number of motile sperm inseminated. We conclude that neither the patients' clinical characteristics nor the parameters evaluated in monitoring human menopausal gonadotropin cycles provide information helpful in predicting which superovulation cycles will result in multiple pregnancy.
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U2 - 10.1016/S0002-9378(88)80089-9
DO - 10.1016/S0002-9378(88)80089-9
M3 - Article
C2 - 3136651
AN - SCOPUS:0023813203
SN - 0002-9378
VL - 159
SP - 382
EP - 385
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 2
ER -