Multiple Separations in Microfabricated Channels: From Biological Microenvironments to DNA

Katherine M. Bullard, Paula Beyer Hietpas, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A continuous sample introduction and separation scheme is presented as an alternative to the current slab gel and microfabricated chip technologies for biological separations. This new technique involves continuous sample introduction via a conventional small bore capillary coupled to a small dimension rectangular channel. Both free zone and size based separations have been carried out in the rectangular channel. Laser induced fluorescence and electrochemical detection schemes have been employed with this technique. Some of the areas this technology has been used to investigate include monitoring dynamic events from microenvironments, monitoring analytes over long periods of time, and performing DNA separations.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalBiomedical Microdevices
Issue number1
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Molecular Biology


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