Multiple transcript initiation as a mechanism for regulating gene expression

Robert E. Farrell, Carole L. Bassett

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


Transcription is the intermediary process that copies a DNA-encoded gene into a form which is either functional in its own right (stable RNAs, such as ribosomal or transfer RNAs) or can be decoded by the translational machinery into a functional protein. Transcripts destined for translation are called messenger RNAs (mRNAs), since they act as go-betweens from DNA to protein. Although RNAs are transcribed as single-stranded molecules, most can assume complicated secondary and tertiary structures that are critical for proper functioning. As a result, each mRNA contains not only the sequence information required to synthesize a protein, but also structural components that can regulate mRNA localization, stability, and translation efficiency. Thus the initiation of transcription occupies a preeminent place in the regulation of gene expression.

Original languageEnglish (US)
Title of host publicationRegulation of Gene Expression in Plants
Subtitle of host publicationThe Role of Transcript Structure and Processing
PublisherSpringer US
Number of pages28
ISBN (Electronic)9780387356402
ISBN (Print)0387354492, 9780387354491
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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