TY - GEN
T1 - Multiplicity of BMP signaling in skeletal development
AU - Wu, Xiangwei
AU - Shi, Weibin
AU - Cao, Xu
PY - 2007/11
Y1 - 2007/11
N2 - Skeletal development and homeostasis are complex processes involving systemic regulatory factors and local factors present in the bone microenvironment. Among these factors, bone morphogenetic proteins (BMPs) represent the major potent bone morphogens, which coordinate with other factors to exert their multiple functions by regulating cell condensation, as well as inducing chondrogenesis and osteogenesis. This article reviews the current status of BMP signaling in skeletal development, with focus on regulation at the level of the receptors. Crosstalk of the BMP pathway with other major signaling pathways is also summarized.
AB - Skeletal development and homeostasis are complex processes involving systemic regulatory factors and local factors present in the bone microenvironment. Among these factors, bone morphogenetic proteins (BMPs) represent the major potent bone morphogens, which coordinate with other factors to exert their multiple functions by regulating cell condensation, as well as inducing chondrogenesis and osteogenesis. This article reviews the current status of BMP signaling in skeletal development, with focus on regulation at the level of the receptors. Crosstalk of the BMP pathway with other major signaling pathways is also summarized.
UR - http://www.scopus.com/inward/record.url?scp=37249015430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37249015430&partnerID=8YFLogxK
U2 - 10.1196/annals.1402.053
DO - 10.1196/annals.1402.053
M3 - Conference contribution
C2 - 18083919
AN - SCOPUS:37249015430
SN - 9781573316842
T3 - Annals of the New York Academy of Sciences
SP - 29
EP - 49
BT - Skeletal Biology and Medicine, Part A
PB - Blackwell Publishing Inc.
ER -