Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction

Richard Mailman; W. Edmundson; K. Muse; Ernest Hodgson

doi:10.1016/0306-3623(77)90027-1

Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction

Richard Mailman, W. Edmundson, K. Muse, Ernest Hodgson

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.

Original language	English (US)
Pages (from-to)	281-284
Number of pages	4
Journal	General Pharmacology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(77)90027-1
State	Published - 1977

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1016/0306-3623(77)90027-1

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title = "Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction",

abstract = "1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.",

author = "Richard Mailman and W. Edmundson and K. Muse and Ernest Hodgson",

note = "Funding Information: *Paper number 5209 of the journal series of the North Carolina Agricultural Experiment Station, Raleigh, NC, U.S.A. Work supported in part, by PHS grant No. ES-00044 from the National Institute of Environmental Health Sciences. t Present address: Department of Psychiatry, Biological Sciences Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.",

year = "1977",

doi = "10.1016/0306-3623(77)90027-1",

language = "English (US)",

volume = "8",

pages = "281--284",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Multiplicity of hepatic cytochrome P-450 in intact microsomes

T2 - Effect of 3-methylcholanthrene induction

AU - Mailman, Richard

AU - Edmundson, W.

AU - Muse, K.

AU - Hodgson, Ernest

N1 - Funding Information: *Paper number 5209 of the journal series of the North Carolina Agricultural Experiment Station, Raleigh, NC, U.S.A. Work supported in part, by PHS grant No. ES-00044 from the National Institute of Environmental Health Sciences. t Present address: Department of Psychiatry, Biological Sciences Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.

PY - 1977

Y1 - 1977

N2 - 1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.

AB - 1. 1. Pre-treatment of rats or mice with 3-methylcholanthrene results in a small increase in total hepatic cytochrome P-450 and a significant change in the spectral characteristics of the isolated microsomes. 2. 2. Subfractionation of the microsomes indicates that at least two different populations of cytochrome P-450 occur, each being characteristic of microsomes of different densities. These cytochrome P-450 fractions differ from those isolated from control or phenobarbital-treated animals.

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U2 - 10.1016/0306-3623(77)90027-1

DO - 10.1016/0306-3623(77)90027-1

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AN - SCOPUS:0018114298

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JO - General Pharmacology

JF - General Pharmacology

IS - 4

ER -

Multiplicity of hepatic cytochrome P-450 in intact microsomes: Effect of 3-methylcholanthrene induction

Abstract

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