TY - JOUR
T1 - Multiplicity of hepatic cytochrome P-450 in intact microsomes
T2 - Effect of phenobarbital induction
AU - Mailman, Richard
AU - Barthalmus, G. T.
AU - Muse, K.
AU - Hodgson, Ernest
N1 - Funding Information:
*Paper number 5210 of the journal series of the North Carolina Agricultural Experiment Station, Raleigh, NC, U.S.A. Work supported in part, by PHS grant No. ES-00044 from the National Institute of Environmental Health Sciences. t Present address: Department of Psychiatry, Biological Sciences Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1977
Y1 - 1977
N2 - 1. 1. Induction of hepatic microsomal cytochrome P-450 by phenobarbital causes distinct qualitative changes in the total cytochrome P-450, including a significant increase in the type I binding per unit of cytochrome. 2. 2. In mice, two distinct populations of cytochrome P-450 can be separated, each characteristic of microsomes of different density. 3. 3. Phenobarbital induction also causes changes in the density distribution of microsomal subfractions.
AB - 1. 1. Induction of hepatic microsomal cytochrome P-450 by phenobarbital causes distinct qualitative changes in the total cytochrome P-450, including a significant increase in the type I binding per unit of cytochrome. 2. 2. In mice, two distinct populations of cytochrome P-450 can be separated, each characteristic of microsomes of different density. 3. 3. Phenobarbital induction also causes changes in the density distribution of microsomal subfractions.
UR - https://www.scopus.com/pages/publications/49349130595
UR - https://www.scopus.com/pages/publications/49349130595#tab=citedBy
U2 - 10.1016/0306-3623(77)90026-X
DO - 10.1016/0306-3623(77)90026-X
M3 - Article
C2 - 590735
AN - SCOPUS:49349130595
SN - 0306-3623
VL - 8
SP - 275
EP - 279
JO - General Pharmacology: The Vascular System
JF - General Pharmacology: The Vascular System
IS - 4
ER -