Muscle sympathetic outflow during horizontal linear acceleration in humans

Jian Cui, Satoshi Iwase, Tadaaki Mano, Naomi Katayama, Shigeo Mori

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at ±0.10, ±0.15, and ±0.20 G was applied in anteroposterior (±Gx, n = 10) or lateral (±Gy, n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.5 ± 6.9, 52.5 ± 4.4, 71.2 ± 9.6, and 67.6 ± 8.2% from the baselines (100%) during linear accelerations with peak values at ±0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.

Original languageEnglish (US)
Pages (from-to)R625-R634
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number2 50-2
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)


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