Mushroom consumption and risk of gastric cancer: A pooled analysis within the stomach cancer pooling project and a combined meta-analysis with other observational studies

Djibril M. Ba, Paddy Ssentongo, Claudio Pelucchi, Eva Negri, Domenico Palli, Monica Ferraroni, Zuo Feng Zhang, Guo Pei Yu, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, David Zaridze, Dmitry Maximovich, Mireia Obón-Santacana, Laura Álvarez-Álvarez, Jesus Vioque, Manoli Garcia De La Hera, Lizbeth López-Carrillo, Malaquias López-Cervantes, Lina MuAreti Lagiou, Pagona Lagiou, Paolo Boffetta, Maria Constanza Camargo, Maria Paula Curado, Nuno Lunet, Carlo La Vecchia, Joshua Muscat

Research output: Contribution to journalArticlepeer-review

Abstract

Edible mushrooms have high concentrations of vitamins and minerals. They are considered 'functional foods' for their disease-prevention properties. Mushroom consumption may reduce the risk of gastric cancer, the fifth most common cancer worldwide. We investigated the association between mushroom consumption and gastric cancer risk in a pooled analysis within the Stomach Cancer Pooling (StoP) Project and in a meta-analysis that also included previously published studies. A total of 3900 gastric cancer cases and 7792 controls from 11 studies were included in the StoP analysis. Mushroom consumption was measured using food frequency questionnaires. Higher mushroom consumption was associated with a lower risk of gastric cancer [relative risk (RR) for the highest vs. lowest consumption categories, 0.82; 95% confidence interval (CI), 0.71-0.95]. The corresponding RRs were 0.59 (95% CI, 0.26-1.33) in a meta-analysis of four previously published studies and 0.77 for all studies combined (95% CI, 0.63-0.95; n = 15 studies). In geographic subgroup analysis, the pooled risk in Western Pacific countries was (RR, 0.59; 95% CI, 0.40-0.87; n = 6). The stronger effect in Asian countries may reflect high level of antioxidants in mushroom species consumed in Asia.

Original languageEnglish (US)
Pages (from-to)222-228
Number of pages7
JournalEuropean Journal of Cancer Prevention
Volume32
Issue number3
DOIs
StatePublished - May 1 2023

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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