TY - JOUR
T1 - Mutagenicity and tumor initiating activity of methylated benzo[b]fluoranthenes
AU - Amin, Shantu
AU - Huie, Keith
AU - Hecht, Stephen S.
N1 - Funding Information:
A Study of Chemical Carcinogenesis, 81. This study was supported by NCI Grant CA-32242. We thank Lynn Radok for her assistance in the tumorigenicity assays, Aibertina Swanson for carrying out the mutagenicity studies, and Lori DeMarco for preparing the manuscript.
PY - 1985/7
Y1 - 1985/7
N2 - The mutagenicity toward S. typhimurium TA 100 and tumor initiating activity on mouse skin of benzo[b]fluoranthene (BbF), 1-methylbenzo[b]fluoranthene (1-MeBbF), 3-MeBbF, 7-MeBbF, 8-MeBbF, 9-MeBbF, 12-MeBbF, 5,6-dimethylbenzo[b]fluoranthene (5,6-diMeBbF) and 1,3-diMeBbF were assayed. Dose-dependent mutagenic activity was observed for BbF, 3-MeBbF, and 1,3-diMeBbF; the other compounds were inactive at the doses tested. 3-MeBbF and 1,3-diMeBbF were strong tumor initiators, with activity greater than that of BbF. All the other compounds were less tumorigenic than BbF. The results suggest that the structural features favoring tumorigenicity of methylated non-alternant polynuclear aromatic hydrocarbons such as BbF are different from those favoring tumorigenicity of methylated alternant polynuclear aromatic hydrocarbons such as benzo[a]pyrene, chrysene and benz[a]anthracene.
AB - The mutagenicity toward S. typhimurium TA 100 and tumor initiating activity on mouse skin of benzo[b]fluoranthene (BbF), 1-methylbenzo[b]fluoranthene (1-MeBbF), 3-MeBbF, 7-MeBbF, 8-MeBbF, 9-MeBbF, 12-MeBbF, 5,6-dimethylbenzo[b]fluoranthene (5,6-diMeBbF) and 1,3-diMeBbF were assayed. Dose-dependent mutagenic activity was observed for BbF, 3-MeBbF, and 1,3-diMeBbF; the other compounds were inactive at the doses tested. 3-MeBbF and 1,3-diMeBbF were strong tumor initiators, with activity greater than that of BbF. All the other compounds were less tumorigenic than BbF. The results suggest that the structural features favoring tumorigenicity of methylated non-alternant polynuclear aromatic hydrocarbons such as BbF are different from those favoring tumorigenicity of methylated alternant polynuclear aromatic hydrocarbons such as benzo[a]pyrene, chrysene and benz[a]anthracene.
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U2 - 10.1093/carcin/6.7.1023
DO - 10.1093/carcin/6.7.1023
M3 - Article
C2 - 3893781
AN - SCOPUS:0021879467
SN - 0143-3334
VL - 6
SP - 1023
EP - 1025
JO - Carcinogenesis
JF - Carcinogenesis
IS - 7
ER -
