Mutual regulation between Hippo signaling and actin cytoskeleton

Yurika Matsui, Zhi Chun Lai

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation, apoptosis, and differentiation. How Hippo signaling is regulated has been under extensive investigation. Over the past three years, an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector, Yki/Yap/Taz. On the other hand, Hippo signaling negatively regulates actin cytoskeleton organization. This review provides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development, and points out outstanding questions for further investigations.

Original languageEnglish (US)
Pages (from-to)904-910
Number of pages7
JournalProtein and Cell
Issue number12
StatePublished - Dec 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology


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