Myc and a Cdk2 senescence switch

Jan Van Riggelen; Dean W. Felsher

doi:10.1038/ncb0110-7

Myc and a Cdk2 senescence switch

Jan Van Riggelen
, Dean W. Felsher

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

Original language	English (US)
Pages (from-to)	7-9
Number of pages	3
Journal	Nature Cell Biology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/ncb0110-7
State	Published - Jan 2010

All Science Journal Classification (ASJC) codes

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncb0110-7

Cite this

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title = "Myc and a Cdk2 senescence switch",

abstract = "Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.",

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AU - Van Riggelen, Jan

AU - Felsher, Dean W.

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AB - Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.

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Myc and a Cdk2 senescence switch

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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