TY - JOUR
T1 - Myelin content changes in probable Alzheimer's disease and mild cognitive impairment
T2 - Associations with age and severity of neuropsychiatric impairment
AU - Kavroulakis, Eleftherios
AU - Simos, Panagiotis G.
AU - Kalaitzakis, Georgios
AU - Maris, Thomas G.
AU - Karageorgou, Dimitra
AU - Zaganas, Ioannis
AU - Panagiotakis, Simeon
AU - Basta, Maria
AU - Vgontzas, Alexandros
AU - Papadaki, Efrosini
N1 - Funding Information:
Contract grant sponsor: Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) – Research Funding Program: THALES, Title of Grant: UOC-Multidisciplinary network for the study of Alzheimer’s Disease; contract grant number: MIS 377299; Contract grant sponsor: Cross-border Cooperation Programme “Greece-Cyprus 2007-2013,” Project Acronym “SKEPSI.”
Publisher Copyright:
© 2017 International Society for Magnetic Resonance in Medicine
PY - 2018/5
Y1 - 2018/5
N2 - Background: Existing indices of white matter integrity such as fractional anisotropy and magnetization transfer ratio may not provide optimal specificity to myelin content. In contrast, myelin water fraction (MWF) derived from the multiecho T 2 relaxation time technique may serve as a more direct measure of myelin content. Purpose/Hypothesis: The goal of the present study was to identify markers of regional demyelination in patients with probable Alzheimer's disease (AD) and mild cognitive impairment (MCI) in relation to age and severity of neuropsychiatric impairment. Population: The sample included patients diagnosed with probable AD (n = 25) or MCI (n = 43), and cognitively intact elderly controls (n = 33). Field Strength/Sequence Assessment: Long T 2 , short T 2 , and MWF values were measured with a 1.5T scanner in periventricular and deep normal-appearing white matter (NAWM), serving as indices of intra/extracellular water content and myelin content. A comprehensive neuropsychological and neuropsychiatric assessment was administered to all participants. Statistical Tests, Results: AD patients displayed higher age-adjusted long and short T 2 values and reduced MWF values in left temporal/parietal and bilateral periventricular NAWM than controls and MCI patients (P < 0.004; one-way analysis of covariance [ANCOVA] tests). Short T 2 /MWF values in temporal, frontal, and periventricular NAWM of controls and/or MCI patients were significantly associated with episodic and semantic memory performance and depressive symptomatology (P < 0.004; partial correlation indices). The impact of age on memory performance was significantly (P < 0.01; mediated linear regression analyses) mediated by age-related changes in short T 2 and MWF values in these regions. Data Conclusion: Age-related demyelination is associated with memory impairment (especially in prodromal dementia states) and symptoms of depression in an anatomically specific manner. Level of Evidence: 1. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;47:1359–1372.
AB - Background: Existing indices of white matter integrity such as fractional anisotropy and magnetization transfer ratio may not provide optimal specificity to myelin content. In contrast, myelin water fraction (MWF) derived from the multiecho T 2 relaxation time technique may serve as a more direct measure of myelin content. Purpose/Hypothesis: The goal of the present study was to identify markers of regional demyelination in patients with probable Alzheimer's disease (AD) and mild cognitive impairment (MCI) in relation to age and severity of neuropsychiatric impairment. Population: The sample included patients diagnosed with probable AD (n = 25) or MCI (n = 43), and cognitively intact elderly controls (n = 33). Field Strength/Sequence Assessment: Long T 2 , short T 2 , and MWF values were measured with a 1.5T scanner in periventricular and deep normal-appearing white matter (NAWM), serving as indices of intra/extracellular water content and myelin content. A comprehensive neuropsychological and neuropsychiatric assessment was administered to all participants. Statistical Tests, Results: AD patients displayed higher age-adjusted long and short T 2 values and reduced MWF values in left temporal/parietal and bilateral periventricular NAWM than controls and MCI patients (P < 0.004; one-way analysis of covariance [ANCOVA] tests). Short T 2 /MWF values in temporal, frontal, and periventricular NAWM of controls and/or MCI patients were significantly associated with episodic and semantic memory performance and depressive symptomatology (P < 0.004; partial correlation indices). The impact of age on memory performance was significantly (P < 0.01; mediated linear regression analyses) mediated by age-related changes in short T 2 and MWF values in these regions. Data Conclusion: Age-related demyelination is associated with memory impairment (especially in prodromal dementia states) and symptoms of depression in an anatomically specific manner. Level of Evidence: 1. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;47:1359–1372.
UR - https://www.scopus.com/pages/publications/85045349943
UR - https://www.scopus.com/pages/publications/85045349943#tab=citedBy
U2 - 10.1002/jmri.25849
DO - 10.1002/jmri.25849
M3 - Article
C2 - 28861929
AN - SCOPUS:85045349943
SN - 1053-1807
VL - 47
SP - 1359
EP - 1372
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -