N-methyl-D-aspartate (NMDA) receptors mediate afferent peripheral chemoreceptor response in the conscious rat

D. Gozal, R. D. Nowak, Y. M. Gozal, J. E. Torres, T. J. Nuckton, G. R. Graff

Research output: Contribution to journalArticlepeer-review


Exogenous L-glutamate increases ventilation (VE) in a dose-dependent manner. In anesthetized dogs, reduced VE responses to hypoxia follow NMDA receptor blockade. To further examine NMDA receptor role in respiratory control, we measured in concious, freely-behaving rats, VE responses to hypercapnia (5% CO), hypoxia (10%O2), and increasing iv sodium cyanide (Cyan) doses, before, and after administration of a non-competitive NMDA receptor antagonist, i.V. 3 mg/kg dizocilpine maleate (MK-801), A significant VE reduction occurred after MK-801 injection, and was primarily due to marked tidal volume decreases, with declines in both inspiratory and expiratory durations. Hypercapnic VE responses were minimally affected after MK-801 (p - NS). In contrast, hypoxic VE responses were markedly attenuated (p < 0.0001). Similarly, Cyan doses associated with significant VE increases were 5 μg/kg and 50 μg/kg in preand post-MK-801 conditions, respectively. Thus, 1-log shifts to the right of individual dose-response curves occurred with MK-801 (p < 0.001). Furthermore, even at Cyan doses eliciting significant VE changes, MK-801 -treated animals had smaller VE increases (P ± 0.01). We conclude that centrally-located neurons expressing NMDA glutamate receptors mediate synaptic relays of peripheral chemoreceptor afferent traffic.

Original languageEnglish (US)
Pages (from-to)79A
JournalJournal of Investigative Medicine
Issue number1
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'N-methyl-D-aspartate (NMDA) receptors mediate afferent peripheral chemoreceptor response in the conscious rat'. Together they form a unique fingerprint.

Cite this