TY - JOUR
T1 - N348I in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine
AU - Yap, Soo Huey
AU - Herman, Brian D.
AU - Radzio, Jessica
AU - Sluis-Cremer, Nicolas
AU - Tachedjian, Gilda
PY - 2012/10/1
Y1 - 2012/10/1
N2 - The efficacy of regimens that include both zidovudine and nevirapine can be explained by the synergistic interactions between these drugs. N348I in HIV-1 reverse transcriptase confers decreased susceptibility to zidovudine and nevirapine. Here, we demonstrate that N348I reverses the synergistic inhibition of HIV-1 by zidovudine and nevirapine. Also, the efficiency of zidovudine-monophosphate excision in the presence of nevirapine is greater for N348I HIV-1 reverse transcriptase compared with the wild-type enzyme. These data help explain the frequent selection of N348I in regimens that contain zidovudine and nevirapine, and suggest that the selection of N348I should be monitored in resource-limited settings where these drugs are routinely used.
AB - The efficacy of regimens that include both zidovudine and nevirapine can be explained by the synergistic interactions between these drugs. N348I in HIV-1 reverse transcriptase confers decreased susceptibility to zidovudine and nevirapine. Here, we demonstrate that N348I reverses the synergistic inhibition of HIV-1 by zidovudine and nevirapine. Also, the efficiency of zidovudine-monophosphate excision in the presence of nevirapine is greater for N348I HIV-1 reverse transcriptase compared with the wild-type enzyme. These data help explain the frequent selection of N348I in regimens that contain zidovudine and nevirapine, and suggest that the selection of N348I should be monitored in resource-limited settings where these drugs are routinely used.
UR - http://www.scopus.com/inward/record.url?scp=84867001877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867001877&partnerID=8YFLogxK
U2 - 10.1097/QAI.0b013e3182657990
DO - 10.1097/QAI.0b013e3182657990
M3 - Article
C2 - 22743599
AN - SCOPUS:84867001877
SN - 1525-4135
VL - 61
SP - 153
EP - 157
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -
