TY - JOUR
T1 - Naltrexone and Coping Skills Therapy for Alcohol Dependence
T2 - A Controlled Study
AU - O'malley, Stephanie S.
AU - Jaffe, Adam J.
AU - Chang, Grace
AU - Schottenfeld, Richard S.
AU - Meyer, Roger E.
AU - Rounsaville, Bruce
N1 - Funding Information:
theNationalInstituteonAlcoholAbuseandAlcoholism:AA-P50-03-onDrugAbuse,KO5-DA-00089.510,AA-08033,andAA-07080anda grant from the National Institute
PY - 1992/11
Y1 - 1992/11
N2 - Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating naltrexone and two manual guided psychotherapies in the treatment of alcohol dependence. Patients were randomized to receive either naltrexone or placebo and either coping skills/relapse prevention therapy or a supportive therapy designed to support the patient's own efforts at abstinence without teaching specific coping skills. Naltrexone proved superior to placebo in measures of drinking and alcohol-related problems, including abstention rates, number of drinking days, relapse, and severity of alcohol-related problems. Medication interacted with the type of psychotherapy received. The cumulative rate of abstinence was highest for patients treated with naltrexone and supportive therapy. For those patients who initiated drinking, however, patients who received naltrexone and coping skills therapy were the least likely to relapse.
AB - Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating naltrexone and two manual guided psychotherapies in the treatment of alcohol dependence. Patients were randomized to receive either naltrexone or placebo and either coping skills/relapse prevention therapy or a supportive therapy designed to support the patient's own efforts at abstinence without teaching specific coping skills. Naltrexone proved superior to placebo in measures of drinking and alcohol-related problems, including abstention rates, number of drinking days, relapse, and severity of alcohol-related problems. Medication interacted with the type of psychotherapy received. The cumulative rate of abstinence was highest for patients treated with naltrexone and supportive therapy. For those patients who initiated drinking, however, patients who received naltrexone and coping skills therapy were the least likely to relapse.
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U2 - 10.1001/archpsyc.1992.01820110045007
DO - 10.1001/archpsyc.1992.01820110045007
M3 - Article
C2 - 1444726
AN - SCOPUS:0026498986
SN - 0003-990X
VL - 49
SP - 881
EP - 887
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 11
ER -
