Nano-enabled delivery of intracellular therapeutics

Fatemeh Ostadhossein, Enrique Alejandro Daza, Daniel Frankowski, Drew Goatz, Molly Imgruet, Joseph Kus, Ryan Lake, Mallika Modak, Nick Olsen, Aaron Schwartz-Duval, Alyssa Zimmer, Nicholas Kolmodin, Dipanjan Pan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Many diseases that plague the modern medical world have their origins at the cellular or molecular level and, as such, require greater specificity to be effectively combated and cured. A number of recent advances in understanding the biology and biochemistry have enabled researchers to develop the specialized tools and techniques needed to detect and provide therapy for these debilitating conditions. Many of these treatments take advantage of the way that cells behave and interact with their environment or various properties of the cell’s structure and form. Researchers are able to surpass a number of cellular hurdles, such as the cell membrane, endosomal escape, and intracellular targeting to begin the arduous task of understanding, diagnosing, and treating diseases like cancer.

Original languageEnglish (US)
Pages (from-to)105-120
Number of pages16
JournalTopics in Medicinal Chemistry
Volume20
DOIs
StatePublished - Jun 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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