Abstract
We report here a novel carrier for intracellular delivery of quantum dots (QDs). Monodisperse hybrid nanoparticles (38 nm in diameter) were prepared by simple mixing of quantum dots and nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH 2). These nanoparticles were immediately adsorbed on to cell surface and effectively internalized into cells. The efficiency of cellular uptake was much higher than that of cationic liposome. In additon, the internalization of QDs with cells was controlled by the amino-group content of CHPNH 2 nanogel. These hybrid nanoparticles could be utilized as a novel fluorescent probe for bioimaging.
Original language | English (US) |
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Pages | 4957-4958 |
Number of pages | 2 |
State | Published - 2005 |
Event | 54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: Sep 20 2005 → Sep 22 2005 |
Conference
Conference | 54th SPSJ Symposium on Macromolecules |
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Country/Territory | Japan |
City | Yamagata |
Period | 9/20/05 → 9/22/05 |
All Science Journal Classification (ASJC) codes
- General Engineering