Nanogel-quantum dot hybrid nanoparticles for live cell imaging

Urara Hasegawa; Shin Ichiro M. Nomura; Sunil C. Kaul; Takashi Hirano; Kazunari Akiyoshi

doi:10.1016/j.bbrc.2005.03.228

Nanogel-quantum dot hybrid nanoparticles for live cell imaging

Urara Hasegawa
, Shin Ichiro M. Nomura
, Sunil C. Kaul
, Takashi Hirano
, Kazunari Akiyoshi

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Abstract

We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH₂). The CHPNH₂-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

Original language	English (US)
Pages (from-to)	917-921
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	331
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.03.228
State	Published - Jun 17 2005

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.03.228

Cite this

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title = "Nanogel-quantum dot hybrid nanoparticles for live cell imaging",

abstract = "We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.",

author = "Urara Hasegawa and Nomura, \{Shin Ichiro M.\} and Kaul, \{Sunil C.\} and Takashi Hirano and Kazunari Akiyoshi",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for “21st COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone” from the Japanese Government. Scientific Research from the Japanese Government (No. 15300158). ",

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doi = "10.1016/j.bbrc.2005.03.228",

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T1 - Nanogel-quantum dot hybrid nanoparticles for live cell imaging

AU - Hasegawa, Urara

AU - Nomura, Shin Ichiro M.

AU - Kaul, Sunil C.

AU - Hirano, Takashi

AU - Akiyoshi, Kazunari

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for “21st COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone” from the Japanese Government. Scientific Research from the Japanese Government (No. 15300158).

PY - 2005/6/17

Y1 - 2005/6/17

N2 - We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

AB - We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Nanogel-quantum dot hybrid nanoparticles for live cell imaging

Abstract

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