@article{f74a0765dceb41a982ed26ae674b7938,
title = "Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality",
abstract = "Magnetic iron oxide nanoparticles (MIONs) have established a niche as a nanomedicine platform for diagnosis and therapy, but they present a challenging surface for ligand functionalization which limits their applications. On the other hand, coating MIONs with another material such as gold to enhance these attachments introduces other complications. Incomplete coating may expose portions of the iron oxide core, or the coating process may alter their magnetic properties. We describe synthesis and characterization of iron oxide/silica/gold core-shell nanoparticles to elucidate the effects of a silica-gold coating process and its impact on the resulting performance. In particular, small angle neutron scattering reveals silica intercalates between iron oxide crystallites that form the dense core, likely preserving the magnetic properties while enabling formation of a continuous gold shell. The synthesized silica-gold-coated MIONs demonstrate magnetic heating properties consistent with the original iron oxide core, with added x-ray contrast for imaging and laser heating.",
author = "Woodard, {Lauren E.} and Dennis, {Cindi L.} and Borchers, {Julie A.} and Anilchandra Attaluri and Esteban Velarde and Charlene Dawidczyk and Searson, {Peter C.} and Pomper, {Martin G.} and Robert Ivkov",
note = "Funding Information: The authors wish to thank C. Gagnon for assistance with SANS measurements, B. Vogelstein for use of DLS equipment, A.K. Woodard for graphics design, W.H. Chowdhury for laser assistance, and V. Chacko for MRI technical support. Research reported in this manuscript was supported by: the National Cancer Institute of the National Institutes of Health under Award Numbers P30CA006973 and T32-CA130840, CCNE grant U54CA151838, R01CA194574, R01CA134675, the Safeway Foundation/Prostate Cancer Foundation, the National Science Foundation under agreement DMR-0944772 and Mr. David H. Koch. This work benefited from the use of the SasView application, originally developed under NSF award DMR-0520547. SasView contains code developed with funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the SINE2020 project, grant agreement No 654000. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-29711-0",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}