Nanoparticle-based protein detection by optical shift of a resonant microcavity

Miguel A. Santiago-Cordoba, Svetlana V. Boriskina, Frank Vollmer, Melik C. Demirel

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


We demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. We quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model.

Original languageEnglish (US)
Article number073701
JournalApplied Physics Letters
Issue number7
StatePublished - Aug 15 2011

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)


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