TY - JOUR
T1 - Nanoporous gold
T2 - 25th Eurosensors Conference
AU - Min, Hwall
AU - Sullivan, Nichole
AU - Allara, David
AU - Tadigadapa, Srinivas
N1 - Funding Information:
This work was supported in part by a grant from the National Science 0925438, and the US Army Research Office Grant # W911NF-07-1-0327.
PY - 2011
Y1 - 2011
N2 - Unambiguous identification of analyte biomolecules with high quantitative sensitivity and specificity continues to be a biosensing challenge. In this work, we demonstrate a micromachined quartz resonator array with nanoporous gold electrode as a highly sensitive substrate for biosensing applications. Furthermore, using surface enhanced Raman spectroscopy (SERS) the nanoporous gold substrate can be used to obtain label free detection of biomolecules with very high selectivity. Enhanced gravimetric sensitivity to 24-mer oligonucleotide binding reaction was achieved due to the increased electrode surface area. This dual mode sensing of biomaterials allows for unique identification of the attached biomolecules on the sensor surface via SERS whereas the quartz resonator provides a very accurate quantitative measure of the analyte. This paper presents the first results on the application of nanoporous gold (np-Au) electroded micromachined quartz resonators for detection of DNA hybridization reaction using simultaneous gravimetric and SERS measurements.
AB - Unambiguous identification of analyte biomolecules with high quantitative sensitivity and specificity continues to be a biosensing challenge. In this work, we demonstrate a micromachined quartz resonator array with nanoporous gold electrode as a highly sensitive substrate for biosensing applications. Furthermore, using surface enhanced Raman spectroscopy (SERS) the nanoporous gold substrate can be used to obtain label free detection of biomolecules with very high selectivity. Enhanced gravimetric sensitivity to 24-mer oligonucleotide binding reaction was achieved due to the increased electrode surface area. This dual mode sensing of biomaterials allows for unique identification of the attached biomolecules on the sensor surface via SERS whereas the quartz resonator provides a very accurate quantitative measure of the analyte. This paper presents the first results on the application of nanoporous gold (np-Au) electroded micromachined quartz resonators for detection of DNA hybridization reaction using simultaneous gravimetric and SERS measurements.
UR - http://www.scopus.com/inward/record.url?scp=84857145016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857145016&partnerID=8YFLogxK
U2 - 10.1016/j.proeng.2011.12.363
DO - 10.1016/j.proeng.2011.12.363
M3 - Conference article
AN - SCOPUS:84857145016
SN - 1877-7058
VL - 25
SP - 1469
EP - 1472
JO - Procedia Engineering
JF - Procedia Engineering
Y2 - 4 September 2011 through 7 September 2011
ER -